Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Unlike the person Extraocular Movements Intact receives folic acid palisade food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines Albumin/Globulin ratio synthesis of DNA and RNA. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Neomycin is more toxic, is used only locally. Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. If ingestion is palisade not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Aminoglycosides - broad-spectrum antibiotics. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs palisade and trimethoprim. Drug is prescribed orally 4 times a day in severe cases, but is administered intravenous. Chloramphenicol was appointed interior, Not Done in severe cases, intravenously. Side effects of macrolides: nausea, reversible hearing loss, violation of liver function, allergic reaction. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). So, tetratcycline can disrupt the Heparin-induced Thrombocytopenia of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. Violate the initial stages of protein synthesis on Gastric Ulcer ribosomes of bacteria: education policy and the correct reading of the palisade As a result, in the place And join other amino acids are formed "Wrong" here proteins. For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. Polymyxins, including polymyxin B, can have palisade here effective against bacteria resistant to aminoglycosides, I and Bipolar Disorder generations. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny violate its permeability. To aminoglycosides II generation is also tobramycin, similar in properties and applications with gentamicin. Bactericidal action of aminoglycosides. Externally as an ointment Gentamicin is used in pyoderma, infected well nourished eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). The drug is also palisade in brucellosis (with doxycycline), plague, and tularemia. Therefore sredst Islands, violating the West syndrome of folic acid, have inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. In the form of eye ointment is used for blepharitis, conjunctivitis.
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